Cancers develop changes in their genes, as well as changes in parts of the cell that control genes. BCOR is a gene that regulates cells by controlling genes, and is changed in a wide range of cancers affecting the blood and organs. By studying a group of more than 20,000 patients with cancer, we saw that the type of BCOR mutation found in a cancer depends on the tissue in which the cancer arises, suggesting that BCOR may have a range of different roles. In patients with endometrial cancer, BCOR mutations are common, and affect a specific part of the gene. The first goal of our study is to describe the clinical impact of BCOR mutations in a large group of patients with endometrial carcinoma. The second goal is to understand how BCOR mutations affect the function and contribute to cancer in cells from different tissues.
R. Coleman Lindsley, M.D., Ph.D.
Location: Dana-Farber Cancer Institute - Massachusetts
Proposal: Defining the role of BCOR mutations in endometrial carcinoma