Pancreatic cancer is a deadly cancer. There are urgent needs to identify specific biomarkers in blood (proteins and metabolites) that are related to pancreatic cancer. The increased understanding of risk factors for pancreatic cancer can be useful to develop new strategy for predicting individual risk of developing this cancer. The proposed study using novel design and methods will help identify protein and metabolite biomarkers in blood causally associated with pancreatic cancer risk. Knowledge generated by this project will help us to better understand the etiology of pancreatic cancer and lay a solid foundation for future efforts of risk prediction of this deadly cancer. The identification of high-risk individuals can be useful for more specific, expensive, and/or invasive tests to identify disease at an early stage or for targeted prevention to reduce disease risk.
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